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Rat Anti-DNER Recombinant Antibody (D1355) (V2LY-0425-LY681)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
D1355
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Recombinant mouse DNER (Ala26-His637).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 µg/ml
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
delta/notch-like EGF repeat containing
Entrez Gene ID
227325
UniProt ID
Q8JZM4
Function
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
Biological Process
Central nervous system development Source: UniProtKB
Endocytosis Source: UniProtKB
Glial cell differentiation Source: Ensembl
Neuron migration Source: UniProtKB
Notch receptor processing Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Skeletal muscle fiber development Source: Ensembl
Synapse assembly Source: UniProtKB
Cellular Location
Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).
Topology
Extracellular: 35-640
Helical: 641-661
Cytoplasmic: 662-737
More Infomation

Campana, I. G., & Silva, G. D. (2021). Anti-Tr/DNER Antibody–Associated Cerebellar Ataxia: a Systematic Review. The Cerebellum, 1-7.

Wang, Z., Li, Z., Wu, Q., Li, C., Li, J., Zhang, Y., ... & Sun, S. (2020). DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell death & disease, 11(8), 1-16.

Ballester-López, C., Conlon, T. M., Ertüz, Z., Greiffo, F. R., Irmler, M., Verleden, S. E., ... & Yildirim, A. Ö. (2019). The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease. EBioMedicine, 43, 562-575.

Wang, L., Wu, Q., Li, Z., Sun, S., Yuan, J., Li, J., ... & Sun, S. (2019). Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cellular signalling, 63, 109389.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Liu, L., ... & Wang, C. (2018). Quantum dot-based immunofluorescent imaging and quantitative detection of DNER and prognostic value in prostate cancer. Cancer Biomarkers, 22(4), 683-691.

Du, J., Wang, X., Zhang, X., Zhang, X., & Jiang, H. (2018). DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. Molecular Medicine Reports, 17(2), 2357-2365.

Keeley, P. W., & Reese, B. E. (2018). DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina. Journal of Comparative Neurology, 526(3), 467-479.

Wang, L., Wu, Q., Zhu, S., Li, Z., Yuan, J., Yu, D., ... & Wang, C. (2017). Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer. American journal of translational research, 9(11), 5031.

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For research use only. Not intended for any clinical use.

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