DNER

DNER (Delta/Notch Like EGF Repeat Containing) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is CRB1.

Full Name

delta/notch-like EGF repeat containing

Function

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Biological Process

Central nervous system development Source: UniProtKB
Endocytosis Source: UniProtKB
Glial cell differentiation Source: Ensembl
Neuron migration Source: UniProtKB
Notch receptor processing Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Skeletal muscle fiber development Source: Ensembl
Synapse assembly Source: UniProtKB

Cellular Location

Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).

Topology

Extracellular: 35-640
Helical: 641-661
Cytoplasmic: 662-737

Anti-DNER antibodies

Mouse Anti-DNER Monoclonal Antibody (DR324-4) (CBMAB-1036-YC)

Datasheet

SDS

Target: DNER

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: DR324-4

Application*: E, WB

Mouse Anti-DNER Monoclonal Antibody (4E8) (CBMAB-1037-YC)

Datasheet

SDS

Target: DNER

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: 4E8

Application*: WB

Mouse Anti-DNER Recombinant Antibody (2F3) (CBMAB-D1354-YC)

Datasheet

SDS

Target: DNER

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 2F3

Application*: E, WB

Rat Anti-DNER Recombinant Antibody (298306) (CBMAB-D1355-YC)

Datasheet

SDS

Target: DNER

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 298306

Application*: IH, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)