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Rabbit Anti-DNTT Recombinant Antibody (CBYJT-1195) (CBMAB-T0209-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to DNTT (DNA Nucleotidylexotransferase). The antibody can be used for immunoassay techniques, such as WB, IHC-P, FC.
See all DNTT antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-1195
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Immunogen
Synthetic peptide within Human TdT aa 100-200 (internal sequence). The exact sequence is proprietary.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 100-200

Target

Full Name
DNA Nucleotidylexotransferase
Introduction
DNTT is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.
Entrez Gene ID
1791
UniProt ID
P04053
Alternative Names
DNA Nucleotidylexotransferase; Terminal Deoxynucleotidyltransferase; Terminal Addition Enzyme; Terminal Transferase; EC 2.7.7.31; TDT
Function
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Biological Process
DNA metabolic process Source: UniProtKB
DNA modification Source: UniProtKB-KW
Double-strand break repair via nonhomologous end joining Source: GO_Central
Response to ATP Source: Ensembl
Cellular Location
Nucleus

Klein, F., Roux, J., Cvijetic, G., Rodrigues, P. F., von Muenchow, L., Lubin, R., ... & Tussiwand, R. (2022). Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors. Nature Immunology, 23(4), 505-517.

Acharya, R., Günder, D., Breuer, T., Schmitz, G., Klauk, H., & Witte, G. (2021). Stability of organic thin-film transistors based on ultrathin films of dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT). Journal of Materials Chemistry C, 9(1), 270-280.

Guo, J., Liu, D., Li, W., Yu, B., Tian, H., Zhu, F., & Yan, D. (2021). High-performance 2, 9-DPh-DNTT organic thin-film transistor by weak epitaxy growth method. Organic Electronics, 93, 106170.

Guo, J., Yu, B., Zhu, F., & Yan, D. (2021). Significant improvement of 2, 9-DPh-DNTT organic thin-film transistors based on organic heterojunction buffer layer. Organic Electronics, 93, 106159.

Sugiyama, M., Jancke, S., Uemura, T., Kondo, M., Inoue, Y., Namba, N., ... & Sekitani, T. (2021). Mobility enhancement of DNTT and BTBT derivative organic thin-film transistors by triptycene molecule modification. Organic Electronics, 96, 106219.

Yamaguchi, Y., Kojiguchi, Y., Kawata, S., Mori, T., Okamoto, K., Tsutsui, M., ... & Yasuda, T. (2020). Solution-processable organic semiconductors featuring S-shaped dinaphthothienothiophene (S-DNTT): Effects of alkyl chain length on self-organization and carrier transport properties. Chemistry of Materials, 32(12), 5350-5360.

Kawabata, K., Usui, S., & Takimiya, K. (2019). Synthesis of soluble dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) derivatives: One-step functionalization of 2-bromo-DNTT. The Journal of Organic Chemistry, 85(1), 195-206.

Za'aba, N. K., Morrison, J. J., & Taylor, D. M. (2017). Effect of relative humidity and temperature on the stability of DNTT transistors: A density of states investigation. Organic Electronics, 45, 174-181.

Breuer, T., Karthäuser, A., Klemm, H., Genuzio, F., Peschel, G., Fuhrich, A., ... & Witte, G. (2017). Exceptional dewetting of organic semiconductor films: the case of dinaphthothienothiophene (DNTT) at dielectric interfaces. ACS Applied Materials & Interfaces, 9(9), 8384-8392.

Wang, X., Zhang, J., Chen, Y., & Chan, P. K. (2017). Molecular dynamics study of thermal transport in a dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) organic semiconductor. Nanoscale, 9(6), 2262-2271.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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