DNTT

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Full Name
DNA Nucleotidylexotransferase
Function
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Biological Process
DNA metabolic process Source: UniProtKB
DNA modification Source: UniProtKB-KW
Double-strand break repair via nonhomologous end joining Source: GO_Central
Response to ATP Source: Ensembl
Cellular Location
Nucleus
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Anti-DNTT antibodies

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Mouse Anti-DNTT Recombinant Antibody (CBYJT-1193) (CBMAB-T0207-YJ)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1193
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DNTT Recombinant Antibody (EG983) (CBMAB-EN1165-LY)

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Target: DNTT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG983
Application*: P
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (CAP647) (CBMAB-AP1935LY)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CAP647
Application*: WB
Datasheet SDS

Rabbit Anti-DNTT Recombinant Antibody (BR161) (CBMAB-BR161LY)

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Target: DNTT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BR161
Application*: P, WB
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (1) (CBMAB-D1461-YC)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 1
Application*: WB
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (4H5) (CBMAB-D1459-YC)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4H5
Application*: E, WB
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (13A11) (CBMAB-D1456-YC)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13A11
Application*: P
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (CBT3841) (V2LY-0625-LY531)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3841
Application*: WB
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (CBT2746) (V2LY-0625-LY530)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT2746
Application*: WB, F
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (CBYJT-1196) (CBMAB-T0210-YJ)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1196
Application*: P, WB
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (CBYJT-1194) (CBMAB-T0208-YJ)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-1194
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DNTT Recombinant Antibody (13A10) (CBMAB-0500-CN)

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Target: DNTT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13A10
Application*: F, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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