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Mouse Anti-DRAM1 Recombinant Antibody (13A174) (CBMAB-D1668-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DNA Damage Regulated Autophagy Modulator 1 (DRAM1). The antibody can be used for immunoassay techniques, such as IHC, WB.
See all DRAM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13A174
Antibody Isotype
IgG1, κ
Application
IHC, WB

Basic Information

Immunogen
Synthetic linear peptide corresponding to human DRAM1 (KLH)
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DNA Damage Regulated Autophagy Modulator 1
Introduction
DRAM1 is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
Entrez Gene ID
55332
UniProt ID
Q8N682
Alternative Names
DNA Damage Regulated Autophagy Modulator 1; Damage-Regulated Autophagy Modulator; DRAM; DNA Damage-Regulated Autophagy Modulator Protein 1; DNA-Damage Regulated Autophagy Modulator 1;
Function
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Biological Process
Apoptotic process Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Regulation of autophagy Source: UniProtKB
Cellular Location
Lysosome membrane

Zhang, Y., Li, X., Li, Y., Li, Y., Wang, Y., Zhu, L., ... & Chen, M. (2021). DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease. Digestive Diseases and Sciences, 66(10), 3375-3390.

Zhang, R., Varela, M., Forn-Cuní, G., Torraca, V., van der Vaart, M., & Meijer, A. H. (2020). Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell death & disease, 11(4), 1-16.

Lu, T., Zhu, Z., Wu, J., She, H., Han, R., Xu, H., & Qin, Z. H. (2019). DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway. Cell Communication and Signaling, 17(1), 1-15.

Wu, X., Qin, Y., Zhu, X., Liu, D., Chen, F., Xu, S., ... & Luo, J. (2018). Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. Journal of molecular and cellular cardiology, 124, 70-82.

Nagata, M., Arakawa, S., Yamaguchi, H., Torii, S., Endo, H., Tsujioka, M., ... & Shimizu, S. (2018). Dram1 regulates DNA damage-induced alternative autophagy. Cell Stress, 2(3), 55.

Chen, C., Liang, Q. Y., Chen, H. K., Wu, P. F., Feng, Z. Y., Ma, X. M., ... & Zhou, G. Q. (2018). DRAM1 regulates the migration and invasion of hepatoblastoma cells via autophagy‑EMT pathway. Oncology Letters, 16(2), 2427-2433.

Meng, C., Liu, Y., Shen, Y., Liu, S., Wang, Z., Ye, Q., ... & Jia, L. (2018). MicroRNA-26b suppresses autophagy in breast cancer cells by targeting DRAM1 mRNA, and is downregulated by irradiation Corrigendum in/10.3892/ol. 2021.12460. Oncology letters, 15(2), 1435-1440.

Memmert, S., Nogueira, A. V. B., Damanaki, A., Nokhbehsaim, M., Eick, S., Divnic-Resnik, T., ... & Deschner, J. (2018). Damage-regulated autophagy modulator 1 in oral inflammation and infection. Clinical oral investigations, 22(8), 2933-2941.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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