DRAM1

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

Full Name

DNA Damage Regulated Autophagy Modulator 1

Function

Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.

Biological Process

Apoptotic process Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Regulation of autophagy Source: UniProtKB

Cellular Location

Lysosome membrane

Anti-DRAM1 antibodies

Mouse Anti-DRAM1 Recombinant Antibody (M3-P4B4) (CBMAB-D1667-YC)

Datasheet

SDS

Target: DRAM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: M3-P4B4

Application*: WB

Mouse Anti-DRAM1 Recombinant Antibody (13A174) (CBMAB-D1668-YC)

Datasheet

SDS

Target: DRAM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 13A174

Application*: IH, WB

Recombinant Mouse Anti-DRAM1 Recombinant Antibody (P4B4) (CBMAB-XB0365-YC)

Datasheet

SDS

Target: DRAM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: P4B4

Application*: E, IH, IF, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)