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Mouse Anti-DRAM1 Recombinant Antibody (D1667) (V2LY-0425-LY916)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
D1667
Antibody Isotype
IgG1, λ
Application
WB, IF, IP

Basic Information

Immunogen
Amino acids 192-201 of human DRAM.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, λ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DNA Damage Regulated Autophagy Modulator 1
Entrez Gene ID
55332
UniProt ID
Q8N682
Function
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Biological Process
Apoptotic process Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Regulation of autophagy Source: UniProtKB
Cellular Location
Lysosome membrane
More Infomation

Zhang, Y., Li, X., Li, Y., Li, Y., Wang, Y., Zhu, L., ... & Chen, M. (2021). DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease. Digestive Diseases and Sciences, 66(10), 3375-3390.

Zhang, R., Varela, M., Forn-Cuní, G., Torraca, V., van der Vaart, M., & Meijer, A. H. (2020). Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell death & disease, 11(4), 1-16.

Lu, T., Zhu, Z., Wu, J., She, H., Han, R., Xu, H., & Qin, Z. H. (2019). DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway. Cell Communication and Signaling, 17(1), 1-15.

Wu, X., Qin, Y., Zhu, X., Liu, D., Chen, F., Xu, S., ... & Luo, J. (2018). Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. Journal of molecular and cellular cardiology, 124, 70-82.

Nagata, M., Arakawa, S., Yamaguchi, H., Torii, S., Endo, H., Tsujioka, M., ... & Shimizu, S. (2018). Dram1 regulates DNA damage-induced alternative autophagy. Cell Stress, 2(3), 55.

Chen, C., Liang, Q. Y., Chen, H. K., Wu, P. F., Feng, Z. Y., Ma, X. M., ... & Zhou, G. Q. (2018). DRAM1 regulates the migration and invasion of hepatoblastoma cells via autophagy‑EMT pathway. Oncology Letters, 16(2), 2427-2433.

Meng, C., Liu, Y., Shen, Y., Liu, S., Wang, Z., Ye, Q., ... & Jia, L. (2018). MicroRNA-26b suppresses autophagy in breast cancer cells by targeting DRAM1 mRNA, and is downregulated by irradiation Corrigendum in/10.3892/ol. 2021.12460. Oncology letters, 15(2), 1435-1440.

Memmert, S., Nogueira, A. V. B., Damanaki, A., Nokhbehsaim, M., Eick, S., Divnic-Resnik, T., ... & Deschner, J. (2018). Damage-regulated autophagy modulator 1 in oral inflammation and infection. Clinical oral investigations, 22(8), 2933-2941.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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