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Mouse Anti-DRD5 Recombinant Antibody (8J1312) (CBMAB-D1695-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dopamine Receptor D5 (DRD5). The antibody can be used for immunoassay techniques, such as WB.
See all DRD5 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
8J1312
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Recombinant rat D1 (D1b) dopamine receptor (within the last 118 of the C-terminus). [Swiss-Prot# P25115].
Specificity
Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Dopamine Receptor D5
Introduction
DRD5 is the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.
Entrez Gene ID
25195
UniProt ID
P25115
Alternative Names
Dopamine Receptor D5; D1beta Dopamine Receptor; D(5) Dopamine Receptor; Dopamine D5 Receptor; DRD1L2; DRD1B; D(1B) Dopamine Receptor; Dopamine Receptor D1B; DBDR;
Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Biological Process
Activation of adenylate cyclase activity Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Associative learning Source: Ensembl
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular response to catecholamine stimulus Source: BHF-UCL
Chemical synaptic transmission Source: UniProtKB
Dopamine receptor signaling pathway Source: GO_Central
Long-term synaptic depression Source: Ensembl
Negative regulation of blood pressure Source: Ensembl
Negative regulation of NAD(P)H oxidase activity Source: UniProtKB
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
Phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of adenylate cyclase activity Source: UniProtKB
Reactive oxygen species metabolic process Source: UniProtKB
Regulation of female receptivity Source: Ensembl
Regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
Response to amphetamine Source: Ensembl
Response to cocaine Source: Ensembl
Sensitization Source: Ensembl
Synaptic transmission, dopaminergic Source: UniProtKB
Transmission of nerve impulse Source: Ensembl
Wound healing Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Benign essential blepharospasm (BEB):
A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Topology
Extracellular: 1-39
Helical: 40-66
Cytoplasmic: 67-77
Helical: 78-104
Extracellular: 105-114
Helical: 115-136
Cytoplasmic: 137-158
Helical: 159-180
Extracellular: 181-223
Helical: 224-246
Cytoplasmic: 247-296
Helical: 297-320
Extracellular: 321-340
Helical: 341-360
Cytoplasmic: 361-477

Osorio-Barrios, F., Navarro, G., Campos, J., Ugalde, V., Prado, C., Raïch, I., ... & Pacheco, R. (2021). The heteromeric complex formed by dopamine receptor D5 and CCR9 leads the gut homing of CD4+ T cells upon inflammation. Cellular and Molecular Gastroenterology and Hepatology, 12(2), 489-506.

Lee, H., Jiang, X., Perwaiz, I., Yu, P., Wang, J., Wang, Y., ... & Jose, P. A. (2021). Dopamine D5 receptor-mediated decreases in mitochondrial reactive oxygen species production are cAMP and autophagy dependent. Hypertension Research, 44(6), 628-641.

Qian, X., Zhang, D., Cao, Z., & Ma, H. (2021). Dopamine pathway mediated by DRD5 facilitates tumor growth via enhancing Warburg effect in esophageal cancer. Frontiers in Oncology, 11, 1039.

Castello, J., Cortés, M., Malave, L., Kottmann, A., Sibley, D. R., Friedman, E., & Rebholz, H. (2020). The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia. Scientific reports, 10(1), 1-12.

Prabhu, V. V., Madhukar, N. S., Gilvary, C., Kline, C. L. B., Oster, S., El-Deiry, W. S., ... & Allen, J. E. (2019). Dopamine receptor D5 is a modulator of tumor response to dopamine receptor D2 antagonism. Clinical Cancer Research, 25(7), 2305-2313.

Alves, L. Q., Alves, J., Ribeiro, R., Ruivo, R., & Castro, F. (2019). The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales. PeerJ, 7, e7758.

Osorio-Barrios, F., Prado, C., Contreras, F., & Pacheco, R. (2018). Dopamine receptor D5 signaling plays a dual role in experimental autoimmune encephalomyelitis potentiating Th17-mediated immunity and favoring suppressive activity of regulatory T-cells. Frontiers in cellular neuroscience, 12, 192.

Leng, Z. G., Lin, S. J., Wu, Z. R., Guo, Y. H., Cai, L., Shang, H. B., ... & Wu, Z. B. (2017). Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. Autophagy, 13(8), 1404-1419.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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