DRD5

DRD5 is the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.

Full Name

Dopamine Receptor D5

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Biological Process

Activation of adenylate cyclase activity Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Associative learning Source: Ensembl
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular response to catecholamine stimulus Source: BHF-UCL
Chemical synaptic transmission Source: UniProtKB
Dopamine receptor signaling pathway Source: GO_Central
Long-term synaptic depression Source: Ensembl
Negative regulation of blood pressure Source: Ensembl
Negative regulation of NAD(P)H oxidase activity Source: UniProtKB
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
Phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of adenylate cyclase activity Source: UniProtKB
Reactive oxygen species metabolic process Source: UniProtKB
Regulation of female receptivity Source: Ensembl
Regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
Response to amphetamine Source: Ensembl
Response to cocaine Source: Ensembl
Sensitization Source: Ensembl
Synaptic transmission, dopaminergic Source: UniProtKB
Transmission of nerve impulse Source: Ensembl
Wound healing Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Benign essential blepharospasm (BEB):
A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.

Topology

Extracellular: 1-39
Helical: 40-66
Cytoplasmic: 67-77
Helical: 78-104
Extracellular: 105-114
Helical: 115-136
Cytoplasmic: 137-158
Helical: 159-180
Extracellular: 181-223
Helical: 224-246
Cytoplasmic: 247-296
Helical: 297-320
Extracellular: 321-340
Helical: 341-360
Cytoplasmic: 361-477