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Mouse Anti-EDF1 Recombinant Antibody (3E6) (CBMAB-A2448-LY)

The product is antibody recognizes EDF1. The antibody 3E6 immunoassay techniques such as: WB, ELISA.
See all EDF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EDF1 (AAH15500.1, 1 a.a. ~ 148 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EDF1
Introduction
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq]
Entrez Gene ID
8721
UniProt ID
O60869
Alternative Names
EDF-1; MBF1; MGC9058
Research Area
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Biological Process
Endothelial cell differentiation Source: UniProtKB
Multicellular organism development Source: ProtInc
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of lipid metabolic process Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
PTM
Phosphorylated (by PKA and PKC).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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