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Rabbit Anti-EGR1 Recombinant Antibody (44D5) (CBMAB-E1004-FY)

This product is rabbit antibody that recognizes EGR1. The antibody 44D5 can be used for immunoassay techniques such as: WB, IP, IF, FC, ChIP.
See all EGR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Cattle
Clone
44D5
Antibody Isotype
IgG
Application
WB, IP, IF, FC, ChIP

Basic Information

Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Early Growth Response 1
Introduction
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene.
Entrez Gene ID
Human1958
Mouse13653
Rat24330
Cattle407125
UniProt ID
HumanP18146
MouseP08046
RatP08154
CattleQ29W20
Alternative Names
Early Growth Response 1; Nerve Growth Factor-Induced Protein A; Transcription Factor ETR103; Zinc Finger Protein 225; Early Growth Response Protein 1; Transcription Factor Zif268; Zinc Finger Protein Krox-24; NGFI-A; ZNF225
Research Area
Transcriptional regulator (PubMed:20121949).

Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity).

Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311).

Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).

Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
Biological Process
BMP signaling pathway Source: Ensembl
Cellular response to gamma radiation Source: Ensembl
Cellular response to heparin Source: UniProtKB
Cellular response to interleukin-8 Source: UniProtKB
Cellular response to mycophenolic acid Source: UniProtKB
Circadian regulation of gene expression Source: UniProtKB
Circadian temperature homeostasis Source: UniProtKB
Estrous cycle Source: UniProtKB
Glomerular mesangial cell proliferation Source: UniProtKB
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Locomotor rhythm Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of chemokine production Source: UniProtKB
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of glomerular metanephric mesangial cell proliferation Source: UniProtKB
Positive regulation of hormone biosynthetic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of apoptotic process Source: Ensembl
Regulation of progesterone biosynthetic process Source: UniProtKB
Regulation of protein sumoylation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: UniProtKB
Response to insulin Source: Ensembl
Response to ischemia Source: UniProtKB
Skeletal muscle cell differentiation Source: Ensembl
T cell differentiation Source: Ensembl
Cellular Location
Nucleus; Cytoplasm

Baek, J., Lopez, P. A., Lee, S., Kim, T. S., Kumar, S., & Schaffer, D. V. (2022). Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment. Science advances, 8(15), eabm4646.

Trizzino, M., Zucco, A., Deliard, S., Wang, F., Barbieri, E., Veglia, F., ... & Gardini, A. (2021). EGR1 is a gatekeeper of inflammatory enhancers in human macrophages. Science advances, 7(3), eaaz8836.

Wang, B., Guo, H., Yu, H., Chen, Y., Xu, H., & Zhao, G. (2021). The role of the transcription factor EGR1 in cancer. Frontiers in Oncology, 11, 642547.

Chen, T., Liu, H., Liu, Z., Li, K., Qin, R., Wang, Y., ... & Xu, Y. (2021). FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis. Oncogene, 40(30), 4941-4953.

Wang, H., Kong, N., Jiao, Y., Dong, S., Sun, D., Chen, X., ... & Shan, T. (2021). EGR1 suppresses porcine epidemic diarrhea virus replication by regulating IRAV to degrade viral nucleocapsid protein. Journal of Virology, 95(19), e00645-21.

Havis, E., & Duprez, D. (2020). EGR1 transcription factor is a multifaceted regulator of matrix production in tendons and other connective tissues. International journal of molecular sciences, 21(5), 1664.

Sun, Z., Xu, X., He, J., Murray, A., Sun, M. A., Wei, X., ... & Xie, H. (2019). EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity. Nature communications, 10(1), 1-12.

Li, L., Ameri, A. H., Wang, S., Jansson, K. H., Casey, O. M., Yang, Q., ... & Kelly, K. (2019). EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis. Oncogene, 38(35), 6241-6255.

Gallo, F. T., Katche, C., Morici, J. F., Medina, J. H., & Weisstaub, N. V. (2018). Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc. Frontiers in behavioral neuroscience, 12, 79.

Liu, H. T., Liu, S., Liu, L., Ma, R. R., & Gao, P. (2018). EGR1-mediated transcription of lncRNA-HNF1A-AS1 promotes cell-cycle progression in gastric cancer. Cancer research, 78(20), 5877-5890.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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