EGR1

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

Early Growth Response 1

Transcriptional regulator (PubMed:20121949).

Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity).

Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311).

Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).

Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).

BMP signaling pathway Source: Ensembl
Cellular response to gamma radiation Source: Ensembl
Cellular response to heparin Source: UniProtKB
Cellular response to interleukin-8 Source: UniProtKB
Cellular response to mycophenolic acid Source: UniProtKB
Circadian regulation of gene expression Source: UniProtKB
Circadian temperature homeostasis Source: UniProtKB
Estrous cycle Source: UniProtKB
Glomerular mesangial cell proliferation Source: UniProtKB
Interleukin-1-mediated signaling pathway Source: BHF-UCL
Locomotor rhythm Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of chemokine production Source: UniProtKB
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of glomerular metanephric mesangial cell proliferation Source: UniProtKB
Positive regulation of hormone biosynthetic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of apoptotic process Source: Ensembl
Regulation of progesterone biosynthetic process Source: UniProtKB
Regulation of protein sumoylation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
Response to glucose Source: Ensembl
Response to hypoxia Source: UniProtKB
Response to insulin Source: Ensembl
Response to ischemia Source: UniProtKB
Skeletal muscle cell differentiation Source: Ensembl
T cell differentiation Source: Ensembl

Nucleus; Cytoplasm