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Mouse Anti-EGR3 Recombinant Antibody (E1011) (V2LY-0425-LY1591)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
E1011
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Immunogen
Amino acids 1-180 of human Egr-3.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Early Growth Response 3
Entrez Gene ID
1960
UniProt ID
Q06889
Research Area
Probable transcription factor involved in muscle spindle development.
Biological Process
Cell migration involved in sprouting angiogenesis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: BHF-UCL
Cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
Circadian rhythm Source: ProtInc
Endothelial cell chemotaxis Source: BHF-UCL
Muscle organ development Source: ProtInc
Negative regulation of apoptotic process Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peripheral nervous system development Source: Ensembl
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of T cell differentiation in thymus Source: Ensembl
Regulation of gamma-delta T cell differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
More Infomation

Zhao, X., Ozols, A. B., Meyers, K. T., Campbell, J., McBride, A., Marballi, K. K., ... & Gallitano, A. L. (2022). Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Molecular Psychiatry, 27(3), 1599-1610.

Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., ... & Lobo, M. K. (2021). Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular Brain, 14(1), 1-14.

Chen, P., Jiang, P., Chen, J., Yang, Y., & Guo, X. (2021). XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis. BMC pulmonary medicine, 21(1), 1-11.

Yang, H., Dong, Y., Zhou, Y., & Li, H. (2021). Overexpression of miR-874-3p alleviates LPS-induced apoptosis and inflammation in alveolar epithelial cell by targeting EGR3/NF-κB. Acta Biochimica Polonica, 68(2), 231-238.

Teng, L., Huang, Y., Guo, J., Li, B., Lin, J., Ma, L., ... & Chen, Q. (2021). Cardiac fibroblast miR‐27a may function as an endogenous anti‐fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3). Journal of cellular and molecular medicine, 25(1), 73-83.

Engeln, M., Mitra, S., Chandra, R., Gyawali, U., Fox, M. E., Dietz, D. M., & Lobo, M. K. (2020). Sex-specific role for Egr3 in nucleus accumbens D2-medium spiny neurons following long-term abstinence from cocaine self-administration. Biological psychiatry, 87(11), 992-1000.

Shin, S. H., Kim, I., Lee, J. E., Lee, M., & Park, J. W. (2020). Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer. Oncogene, 39(36), 5839-5854.

Kim, K. H., Shim, J. S., Kim, H. J., & Son, E. D. (2020). Penta-O-galloyl-β-D-glucose from Paeonia lactiflora Pall. root extract enhances the expression of skin barrier genes via EGR3. Journal of ethnopharmacology, 248, 112337.

Li, X., Yuan, M., Song, L., & Wang, Y. (2020). Silencing of microRNA-210 inhibits the progression of liver cancer and hepatitis B virus-associated liver cancer via targeting EGR3. BMC Medical Genetics, 21(1), 1-9.

Meyers, K. T., Marballi, K. K., Brunwasser, S. J., Renda, B., Charbel, M., Marrone, D. F., & Gallitano, A. L. (2018). The immediate early gene Egr3 is required for hippocampal induction of Bdnf by electroconvulsive stimulation. Frontiers in behavioral neuroscience, 12, 92.

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For research use only. Not intended for any clinical use.

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