EGR3

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Full Name

Early Growth Response 3

Research Area

Probable transcription factor involved in muscle spindle development.

Biological Process

Cell migration involved in sprouting angiogenesis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: BHF-UCL
Cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
Circadian rhythm Source: ProtInc
Endothelial cell chemotaxis Source: BHF-UCL
Muscle organ development Source: ProtInc
Negative regulation of apoptotic process Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peripheral nervous system development Source: Ensembl
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of T cell differentiation in thymus Source: Ensembl
Regulation of gamma-delta T cell differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus