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Mouse Anti-EGR3 Recombinant Antibody (A-7) (CBMAB-E1011-FY)

This product is mouse antibody that recognizes EGR3. The antibody A-7 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all EGR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A-7
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Early Growth Response 3
Introduction
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
1960
UniProt ID
Q06889
Alternative Names
Early Growth Response 3; Zinc Finger Protein Pilot; EGR-3; PILOT; Early Growth Response Protein 3
Research Area
Probable transcription factor involved in muscle spindle development.
Biological Process
Cell migration involved in sprouting angiogenesis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: BHF-UCL
Cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
Circadian rhythm Source: ProtInc
Endothelial cell chemotaxis Source: BHF-UCL
Muscle organ development Source: ProtInc
Negative regulation of apoptotic process Source: BHF-UCL
Neuromuscular synaptic transmission Source: Ensembl
Peripheral nervous system development Source: Ensembl
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of T cell differentiation in thymus Source: Ensembl
Regulation of gamma-delta T cell differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Zhao, X., Ozols, A. B., Meyers, K. T., Campbell, J., McBride, A., Marballi, K. K., ... & Gallitano, A. L. (2022). Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Molecular Psychiatry, 27(3), 1599-1610.

Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., ... & Lobo, M. K. (2021). Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation. Molecular Brain, 14(1), 1-14.

Chen, P., Jiang, P., Chen, J., Yang, Y., & Guo, X. (2021). XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis. BMC pulmonary medicine, 21(1), 1-11.

Yang, H., Dong, Y., Zhou, Y., & Li, H. (2021). Overexpression of miR-874-3p alleviates LPS-induced apoptosis and inflammation in alveolar epithelial cell by targeting EGR3/NF-κB. Acta Biochimica Polonica, 68(2), 231-238.

Teng, L., Huang, Y., Guo, J., Li, B., Lin, J., Ma, L., ... & Chen, Q. (2021). Cardiac fibroblast miR‐27a may function as an endogenous anti‐fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3). Journal of cellular and molecular medicine, 25(1), 73-83.

Engeln, M., Mitra, S., Chandra, R., Gyawali, U., Fox, M. E., Dietz, D. M., & Lobo, M. K. (2020). Sex-specific role for Egr3 in nucleus accumbens D2-medium spiny neurons following long-term abstinence from cocaine self-administration. Biological psychiatry, 87(11), 992-1000.

Shin, S. H., Kim, I., Lee, J. E., Lee, M., & Park, J. W. (2020). Loss of EGR3 is an independent risk factor for metastatic progression in prostate cancer. Oncogene, 39(36), 5839-5854.

Kim, K. H., Shim, J. S., Kim, H. J., & Son, E. D. (2020). Penta-O-galloyl-β-D-glucose from Paeonia lactiflora Pall. root extract enhances the expression of skin barrier genes via EGR3. Journal of ethnopharmacology, 248, 112337.

Li, X., Yuan, M., Song, L., & Wang, Y. (2020). Silencing of microRNA-210 inhibits the progression of liver cancer and hepatitis B virus-associated liver cancer via targeting EGR3. BMC Medical Genetics, 21(1), 1-9.

Meyers, K. T., Marballi, K. K., Brunwasser, S. J., Renda, B., Charbel, M., Marrone, D. F., & Gallitano, A. L. (2018). The immediate early gene Egr3 is required for hippocampal induction of Bdnf by electroconvulsive stimulation. Frontiers in behavioral neuroscience, 12, 92.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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