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Mouse Anti-EHD3 Recombinant Antibody (4B7) (CBMAB-A2508-LY)

The product is antibody recognizes EHD3. The antibody 4B7 immunoassay techniques such as: WB, ELISA.
See all EHD3 antibodies
Published Data
Fig.1 Stacks were deconvoluted and single optical sections are shown.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EHD3 (NP_055415, 357 a.a. ~ 406 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
EH-domain containing 3
Entrez Gene ID
30845
UniProt ID
Q9NZN3
Alternative Names
PAST3
Research Area
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250).

In vitro causes tubulation of endocytic membranes (PubMed:24019528).

Binding to phosphatidic acid induces its membrane tubulation activity (By similarity).

Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025).

Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287).

Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164).

Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity).

In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity).

Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025).

Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity).

Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).
Biological Process
Cilium assembly Source: UniProtKB
Early endosome to Golgi transport Source: UniProtKB
Endocytic recycling Source: UniProtKB
Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central
Golgi to lysosome transport Source: UniProtKB
Positive regulation of voltage-gated calcium channel activity Source: Ensembl
Protein homooligomerization Source: UniProtKB
Protein localization to plasma membrane Source: MGI
Protein transport Source: UniProtKB-KW
Receptor recycling Source: UniProtKB
Regulation of cardiac conduction Source: Ensembl
Regulation of cardiac muscle cell membrane potential Source: MGI
Regulation of cardiac muscle contraction Source: Ensembl
Regulation of Golgi organization Source: UniProtKB
Cellular Location
Recycling endosome membrane; Cell membrane; Cilium membrane. Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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