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Mouse Anti-ELF3 Recombinant Antibody (ELF3B10C4) (CBMAB-E1217-FY)

This product is mouse antibody that recognizes ELF3. The antibody ELF3B10C4 can be used for immunoassay techniques such as: DB.
See all ELF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
ELF3B10C4
Antibody Isotype
IgG1
Application
DB

Basic Information

Immunogen
ELF3 antibody was raised in mouse using recombinant E74-Like Factor 3
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELF3
Introduction
ELF3 (E74 Like ETS Transcription Factor 3) is a Protein Coding gene. Diseases associated with ELF3 include Sarcoma, Synovial and Isolated Growth Hormone Deficiency, Type Ii. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is EHF.
Entrez Gene ID
1999
UniProt ID
P78545
Alternative Names
E74 Like ETS Transcription Factor 3; E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific ); Epithelium-Specific Ets Transcription Factor 1; Epithelial-Restricted With Serine Box; Epithelium-Restricted Ets Protein ESX; ESE-1; ESX; ERT
Research Area
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Biological Process
Blastocyst development Source: Ensembl
Cell differentiation Source: GO_Central
Epithelial cell differentiation Source: InterPro
Extracellular matrix organization Source: Ensembl
Inflammatory response Source: UniProtKB
Mammary gland involution Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: InterPro
Cellular Location
Nucleus; Cytoplasm. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.

Zhang, L. L., Li, W., Tian, Y. Y., Davis, S. J., & Liu, J. X. (2021). The E3 ligase XBAT35 mediates thermoresponsive hypocotyl growth by targeting ELF3 for degradation in Arabidopsis. Journal of Integrative Plant Biology, 63(6), 1097-1103.

Li, D., She, J., Hu, X., Zhang, M., Sun, R., & Qin, S. (2021). The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis. Oncogene, 40(35), 5403-5415.

Zhao, H., Xu, D., Tian, T., Kong, F., Lin, K., Gan, S., ... & Li, G. (2021). Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis. Plant Science, 303, 110786.

Zhang, L. L., Shao, Y. J., Ding, L., Wang, M. J., Davis, S. J., & Liu, J. X. (2021). XBAT31 regulates thermoresponsive hypocotyl growth through mediating degradation of the thermosensor ELF3 in Arabidopsis. Science Advances, 7(19), eabf4427.

Jung, J. H., Barbosa, A. D., Hutin, S., Kumita, J. R., Gao, M., Derwort, D., ... & Wigge, P. A. (2020). A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature, 585(7824), 256-260.

Wang, J., Shen, X., Liu, J., Chen, W., Wu, F., Wu, W., ... & Miao, C. (2020). High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression. Cell death & disease, 11(5), 1-14.

Pandey, A., Stawiski, E. W., Durinck, S., Gowda, H., Goldstein, L. D., Barbhuiya, M. A., ... & Seshagiri, S. (2020). Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. Nature communications, 11(1), 1-13.

Ke, Z., Xie, F., Zheng, C., & Chen, D. (2019). CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR‐4288‐induced ELF3 inhibition. Journal of Cellular Physiology, 234(2), 1699-1706.

Luk, I. Y., Reehorst, C. M., & Mariadason, J. M. (2018). ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer. Molecules, 23(9), 2191.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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