Rabbit Anti-ELOA Recombinant Antibody (EG1091) (CBMAB-EN1287-LY)

The product is antibody recognizes ELOA1. The antibody EG1091 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all ELOA antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1091

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human ELOA1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Elongin A

Entrez Gene ID

Human	6924
Mouse	27224
Rat	25562

UniProt ID

Human	Q14241
Mouse	Q8CB77
Rat	Q63187

Research Area

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Biological Process

Regulation of transcription by RNA polymerase II Source: ProtInc
Transcription elongation from RNA polymerase II promoter Source: InterPro

Cellular Location

Nucleus

References

Hu, L., Zhang, W., Xiang, Z., Wang, Y., Zeng, C., Wang, X., ... & Chen, L. (2022). EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity. Platelets, 33(5), 755-763.

Ardehali, M. B., Damle, M., Perea-Resa, C., Blower, M. D., & Kingston, R. E. (2021). Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo. Journal of Biological Chemistry, 296.

Wang, Y., Hou, L., Ardehali, M. B., Kingston, R. E., & Dynlacht, B. D. (2021). Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity. Journal of Biological Chemistry, 296.

Sanchez, G., Barbier, J., Elie, C., Kiernan, R., & Rouquier, S. (2020). PAF1 facilitates RNA polymerase II ubiquitination by the Elongin A complex through phosphorylation by CDK12. bioRxiv.

Weems, J. C., Conaway, J., & Conaway, R. (2019). Elongin and the Elongin A ubiquitin ligase complex in transcription and the response to DNA damage. The FASEB Journal, 33(S1), 457-28.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ELOA Recombinant Antibody (3E2)

Mouse Anti-ELOA Recombinant Antibody (CBYJT-1213)

Mouse Anti-ELOA Recombinant Antibody (CBYJT-1212)

Mouse Anti-ELOA Recombinant Antibody (1F3)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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