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Mouse Anti-ELOA Recombinant Antibody (CBYJT-1213) (CBMAB-T0227-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to ELOA (Elongin A). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ELOA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1213
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Elongin A
Introduction
ELOA is the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. ELOA activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A plays a role as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Entrez Gene ID
6924
UniProt ID
Q14241
Alternative Names
Elongin A; Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A); RNA Polymerase II Transcription Factor SIII Subunit A1; Transcription Elongation Factor B Polypeptide 3; Transcription Elongation Factor B Subunit 3; Elongin 110 KDa Subunit; SIII P110
Research Area
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Biological Process
Regulation of transcription by RNA polymerase II Source: ProtInc
Transcription elongation from RNA polymerase II promoter Source: InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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