Mouse Anti-EMSY Recombinant Antibody (CBLC217-LY) (CBMAB-C11482-LY)

The product is antibody recognizes EMSY. The antibody CBLC217-LY immunoassay techniques such as: ELISA, IF, WB.
See all EMSY antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLC217-LY

Antibody Isotype

IgG3, κ

Application

ELISA, IF, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

EMSY, BRCA2 Interacting Transcriptional Repressor

Introduction

EMSY (EMSY, BRCA2 Interacting Transcriptional Repressor) is a Protein Coding gene. Diseases associated with EMSY include Sporadic Breast Cancer and Breast Cancer. Among its related pathways are Mesodermal Commitment Pathway.

Entrez Gene ID

56946

UniProt ID

Q7Z589

Alternative Names

EMSY, BRCA2 Interacting Transcriptional Repressor; C11orf30; BRCA2-Interacting Transcriptional Repressor EMSY; Chromosome 11 Open Reading Frame 30; Protein EMSY; GL002;

Research Area

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845).

Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845).

Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338).

Biological Process

Chromatin organization Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus. Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.

PTM

O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.

References

Marzio, A., Kurz, E., Sahni, J. M., Di Feo, G., Puccini, J., Jiang, S., ... & Pagano, M. (2022). EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion. Cell, 185(1), 169-183.

Zhang, M., Chen, G., Wang, Y., Wu, S. Q., Sandford, A. J., & He, J. Q. (2020). Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility. BMC pulmonary medicine, 20(1), 1-9.

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., ... & Brown, S. J. (2019). EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Journal of Allergy and Clinical Immunology, 144(2), 470-481.

Milutinovic, M., Lindsey III, B. E., Wijeratne, A., Hernandez, J. M., Grotewold, N., Fernández, V., ... & Brkljacic, J. (2019). Arabidopsis EMSY-like (EML) histone readers are necessary for post-fertilization seed development, but prevent fertilization-independent seed formation. Plant Science, 285, 99-109.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-EMSY Recombinant Antibody (CBFYE-0835)

Mouse Anti-EMSY Recombinant Antibody (CBFYE-0834)

Mouse Anti-EMSY Recombinant Antibody (5D1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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