Mouse Anti-EMSY Recombinant Antibody (CBFYE-0834) (CBMAB-E1289-FY)

Name: Mouse Anti-EMSY Recombinant Antibody (CBFYE-0834)
SKU: CBMAB-E1289-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0834

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1-83 mapping at the N-terminus of human EMSY.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

EMSY, BRCA2 Interacting Transcriptional Repressor

Introduction

EMSY (EMSY, BRCA2 Interacting Transcriptional Repressor) is a Protein Coding gene. Diseases associated with EMSY include Sporadic Breast Cancer and Breast Cancer. Among its related pathways are Mesodermal Commitment Pathway.

Entrez Gene ID

56946

UniProt ID

Q7Z589

Alternative Names

EMSY, BRCA2 Interacting Transcriptional Repressor; C11orf30; BRCA2-Interacting Transcriptional Repressor EMSY; Chromosome 11 Open Reading Frame 30; Protein EMSY; GL002

Research Area

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845).

Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845).

Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338).

Biological Process

Chromatin organization Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus. Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.

PTM

O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.

Marzio, A., Kurz, E., Sahni, J. M., Di Feo, G., Puccini, J., Jiang, S., ... & Pagano, M. (2022). EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion. Cell, 185(1), 169-183.

Zhang, M., Chen, G., Wang, Y., Wu, S. Q., Sandford, A. J., & He, J. Q. (2020). Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility. BMC pulmonary medicine, 20(1), 1-9.

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., ... & Brown, S. J. (2019). EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Journal of Allergy and Clinical Immunology, 144(2), 470-481.

Milutinovic, M., Lindsey III, B. E., Wijeratne, A., Hernandez, J. M., Grotewold, N., Fernández, V., ... & Brkljacic, J. (2019). Arabidopsis EMSY-like (EML) histone readers are necessary for post-fertilization seed development, but prevent fertilization-independent seed formation. Plant Science, 285, 99-109.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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