EMSY

EMSY (EMSY, BRCA2 Interacting Transcriptional Repressor) is a Protein Coding gene. Diseases associated with EMSY include Sporadic Breast Cancer and Breast Cancer. Among its related pathways are Mesodermal Commitment Pathway.

Full Name

EMSY, BRCA2 Interacting Transcriptional Repressor

Research Area

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845).

Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845).

Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338).

Biological Process

Chromatin organization Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus. Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.

PTM

O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.

Anti-EMSY antibodies

Mouse Anti-EMSY Recombinant Antibody (CBFYE-0835) (CBMAB-E1290-FY)

Datasheet

SDS

Target: EMSY

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYE-0835

Application*: WB, IP, IF, E

Mouse Anti-EMSY Recombinant Antibody (CBFYE-0834) (CBMAB-E1289-FY)

Datasheet

SDS

Target: EMSY

Host: Mouse

Specificity: Human

Clone: CBFYE-0834

Application*: WB, IP, IF, P, E

Mouse Anti-EMSY Recombinant Antibody (CBLC217-LY) (CBMAB-C11482-LY)

Datasheet

SDS

Target: EMSY

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBLC217-LY

Application*: E, IF, WB

Mouse Anti-EMSY Recombinant Antibody (5D1) (CBMAB-A0926-LY)

Datasheet

SDS

Target: EMSY

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 5D1

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)