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Mouse Anti-ESM1 (AA 85-185) Recombinant Antibody (CBFYE-1233) (CBMAB-E1803-FY)

This product is mouse antibody that recognizes ESM1. The antibody CBFYE-1233 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all ESM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1233
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa85-185 from human ESM1 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 85-185

Target

Full Name
endothelial cell-specific molecule 1
Introduction
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
11082
UniProt ID
Q9NQ30
Alternative Names
Endothelial Cell Specific Molecule 1; Endothelial Cell-Specific Molecule 1; ESM-1; Endocan
Research Area
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
Biological Process
Angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB
Cellular Location
Secreted
PTM
May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.

Hong, H. J., Oh, Y. I., Park, S. M., An, J. H., Kim, T. H., Chae, H. K., ... & Youn, H. Y. (2022). Evaluation of endothelial cell-specific molecule-1 as a biomarker of glycocalyx damage in canine myxomatous mitral valve disease. BMC Veterinary Research, 18(1), 1-8.

Li, J., Jiang, H., Peng, P., Zhang, Q., Bai, W., Yang, Y., ... & Shao, J. (2022). Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury. Biomedicine & Pharmacotherapy, 153, 113455.

He, Y., Lin, L., Ou, Y., Hu, X., Xu, C., & Wang, C. (2022). Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. Open Medicine, 17(1), 1376-1389.

Zheng, X., Higdon, L., Gaudet, A., Shah, M., Balistieri, A., Li, C., ... & Bhalla, V. (2021). Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. bioRxiv.

Hung, T. W., Chu, C. Y., Yu, C. L., Lee, C. C., Hsu, L. S., Chen, Y. S., ... & Tsai, J. P. (2020). Endothelial cell-specific molecule 1 promotes endothelial to mesenchymal transition in renal Fibrosis. Toxins, 12(8), 506.

Zhang, Y., Chen, P., Cai, S., Li, J., & Chen, Y. (2020). Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients. Iranian Journal of Basic Medical Sciences, 23(12), 1610.

Ovayolu, A., Ovayolu, G., Yuce, T., Ozek, M. A., Dogan, I., & Bostancieri, N. (2020). Amniotic fluid concentrations of soluble endoglin and endothelial cell-specific molecule-1 in pregnancies complicated with neural tube defects. Journal of Perinatal Medicine, 48(2), 132-138.

Wang, S., Wu, Z., Wei, L., & Zhang, J. (2019). Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma. BMC Endocrine Disorders, 19(1), 1-7.

Gündoğan, F., Bayram, A., Kalkan, M., & Özcan, I. (2018). Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss. The Journal of Laryngology & Otology, 132(11), 995-999.

Schuitemaker, J. H., Cremers, T. I., Van Pampus, M. G., Scherjon, S. A., & Faas, M. M. (2018). Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies. Pregnancy Hypertension, 12, 58-64.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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