ESM1
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
endothelial cell-specific molecule 1
Research Area
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
Biological Process
Angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB
Cellular Location
Secreted
PTM
May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
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Anti-ESM1 antibodies
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Target: ESM1
Sensitivity: 0.0026 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Esm1
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Esm1
Sensitivity: 0.163 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: ESM1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-184
Tag: His Tag
Target: ESM1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-184
Tag: His Tag
Target: ESM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 6D4
Application*: WB, E, IH
Target: ESM1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYE-1234
Application*: WB
Target: ESM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1233
Application*: WB, IP, IF, E
Target: ESM1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYE-1231
Application*: WB, N, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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