Human ESM1 ELISA Kit (V2LY-0626-LY3656)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0026 ng/mL
Detection Range
0.005-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
20.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
endothelial cell-specific molecule 1
Research Area
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
Biological Process
Angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB
Cellular Location
Secreted
PTM
May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.

Hong, H. J., Oh, Y. I., Park, S. M., An, J. H., Kim, T. H., Chae, H. K., ... & Youn, H. Y. (2022). Evaluation of endothelial cell-specific molecule-1 as a biomarker of glycocalyx damage in canine myxomatous mitral valve disease. BMC Veterinary Research, 18(1), 1-8.

Li, J., Jiang, H., Peng, P., Zhang, Q., Bai, W., Yang, Y., ... & Shao, J. (2022). Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury. Biomedicine & Pharmacotherapy, 153, 113455.

He, Y., Lin, L., Ou, Y., Hu, X., Xu, C., & Wang, C. (2022). Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. Open Medicine, 17(1), 1376-1389.

Zheng, X., Higdon, L., Gaudet, A., Shah, M., Balistieri, A., Li, C., ... & Bhalla, V. (2021). Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. bioRxiv.

Hung, T. W., Chu, C. Y., Yu, C. L., Lee, C. C., Hsu, L. S., Chen, Y. S., ... & Tsai, J. P. (2020). Endothelial cell-specific molecule 1 promotes endothelial to mesenchymal transition in renal Fibrosis. Toxins, 12(8), 506.

Zhang, Y., Chen, P., Cai, S., Li, J., & Chen, Y. (2020). Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients. Iranian Journal of Basic Medical Sciences, 23(12), 1610.

Ovayolu, A., Ovayolu, G., Yuce, T., Ozek, M. A., Dogan, I., & Bostancieri, N. (2020). Amniotic fluid concentrations of soluble endoglin and endothelial cell-specific molecule-1 in pregnancies complicated with neural tube defects. Journal of Perinatal Medicine, 48(2), 132-138.

Wang, S., Wu, Z., Wei, L., & Zhang, J. (2019). Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma. BMC Endocrine Disorders, 19(1), 1-7.

Gündoğan, F., Bayram, A., Kalkan, M., & Özcan, I. (2018). Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss. The Journal of Laryngology & Otology, 132(11), 995-999.

Schuitemaker, J. H., Cremers, T. I., Van Pampus, M. G., Scherjon, S. A., & Faas, M. M. (2018). Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies. Pregnancy Hypertension, 12, 58-64.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY3968)

Mouse Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY8284)

Rat Esm1 ELISA Kit (CAT#: V2LY-0626-LY1295)

Mouse Esm1 ELISA Kit (CAT#: V2LY-0626-LY1491)

Related Products

Mouse Anti-ESM1 Recombinant Antibody (CBFYE-1233) (CAT#: V2LY-0825-LY763)

Mouse Esm1 ELISA Kit (CAT#: V2LY-0626-LY1491)

Human Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY3968)

Rat Anti-ESM1 Recombinant Antibody (CBFYE-1231) (CAT#: V2LY-0825-LY762)

Rat Anti-ESM1 Recombinant Antibody (CBFYE-1234) (CAT#: V2LY-0825-LY764)

Rat Esm1 ELISA Kit (CAT#: V2LY-0626-LY1295)

Mouse Anti-ESM1 Recombinant Antibody (6D4) (CAT#: V2LY-0825-LY765)

Mouse Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY8284)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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