Rat Anti-ESM1 Recombinant Antibody (CBFYE-1231) (V2LY-0825-LY762)

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Basic Information

Host Animal
Rat
Clone
CBFYE-1231
Application
WB, Neutralization, ELISA
Immunogen
Recombinant mouse ESM-1 (Trp20-Arg184).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA2-8 μg/ml
WB1 μg/ml
Neutralization1-3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
endothelial cell-specific molecule 1
Entrez Gene ID
UniProt ID
Research Area
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
Biological Process
Angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB
Cellular Location
Secreted
PTM
May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.

Hong, H. J., Oh, Y. I., Park, S. M., An, J. H., Kim, T. H., Chae, H. K., ... & Youn, H. Y. (2022). Evaluation of endothelial cell-specific molecule-1 as a biomarker of glycocalyx damage in canine myxomatous mitral valve disease. BMC Veterinary Research, 18(1), 1-8.

Li, J., Jiang, H., Peng, P., Zhang, Q., Bai, W., Yang, Y., ... & Shao, J. (2022). Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury. Biomedicine & Pharmacotherapy, 153, 113455.

He, Y., Lin, L., Ou, Y., Hu, X., Xu, C., & Wang, C. (2022). Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. Open Medicine, 17(1), 1376-1389.

Zheng, X., Higdon, L., Gaudet, A., Shah, M., Balistieri, A., Li, C., ... & Bhalla, V. (2021). Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. bioRxiv.

Hung, T. W., Chu, C. Y., Yu, C. L., Lee, C. C., Hsu, L. S., Chen, Y. S., ... & Tsai, J. P. (2020). Endothelial cell-specific molecule 1 promotes endothelial to mesenchymal transition in renal Fibrosis. Toxins, 12(8), 506.

Zhang, Y., Chen, P., Cai, S., Li, J., & Chen, Y. (2020). Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients. Iranian Journal of Basic Medical Sciences, 23(12), 1610.

Ovayolu, A., Ovayolu, G., Yuce, T., Ozek, M. A., Dogan, I., & Bostancieri, N. (2020). Amniotic fluid concentrations of soluble endoglin and endothelial cell-specific molecule-1 in pregnancies complicated with neural tube defects. Journal of Perinatal Medicine, 48(2), 132-138.

Wang, S., Wu, Z., Wei, L., & Zhang, J. (2019). Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma. BMC Endocrine Disorders, 19(1), 1-7.

Gündoğan, F., Bayram, A., Kalkan, M., & Özcan, I. (2018). Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss. The Journal of Laryngology & Otology, 132(11), 995-999.

Schuitemaker, J. H., Cremers, T. I., Van Pampus, M. G., Scherjon, S. A., & Faas, M. M. (2018). Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies. Pregnancy Hypertension, 12, 58-64.

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For research use only. Not intended for any clinical use.

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