Human Recombinant ESM1 protein, His Tag (V2LY-0526-LY3968)

Name: Human Recombinant ESM1 protein, His Tag
SKU: V2LY-0526-LY3968
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ESM1 protein, His Tag consist of Amino Acid: 1-184 and predicts a molecular mass of 19.6 kDa.

Molecule Mass

19.6 kDa

Sequence

Amino Acid: 1-184

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

endothelial cell-specific molecule 1

Research Area

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

Biological Process

Angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
Sprouting angiogenesis Source: UniProtKB

Cellular Location

Secreted

PTM

May contain intrachain disulfide bonds.
O-glycosylated; contains chondroitin sulfate and dermatan sulfate.

Hong, H. J., Oh, Y. I., Park, S. M., An, J. H., Kim, T. H., Chae, H. K., ... & Youn, H. Y. (2022). Evaluation of endothelial cell-specific molecule-1 as a biomarker of glycocalyx damage in canine myxomatous mitral valve disease. BMC Veterinary Research, 18(1), 1-8.

Li, J., Jiang, H., Peng, P., Zhang, Q., Bai, W., Yang, Y., ... & Shao, J. (2022). Biliverdin modulates the long non-coding RNA H19/microRNA-181b-5p/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury. Biomedicine & Pharmacotherapy, 153, 113455.

He, Y., Lin, L., Ou, Y., Hu, X., Xu, C., & Wang, C. (2022). Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. Open Medicine, 17(1), 1376-1389.

Zheng, X., Higdon, L., Gaudet, A., Shah, M., Balistieri, A., Li, C., ... & Bhalla, V. (2021). Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. bioRxiv.

Hung, T. W., Chu, C. Y., Yu, C. L., Lee, C. C., Hsu, L. S., Chen, Y. S., ... & Tsai, J. P. (2020). Endothelial cell-specific molecule 1 promotes endothelial to mesenchymal transition in renal Fibrosis. Toxins, 12(8), 506.

Zhang, Y., Chen, P., Cai, S., Li, J., & Chen, Y. (2020). Decreased expression of endothelial cell specific molecule-1 in lung tissue in emphysematous mice and stable COPD patients. Iranian Journal of Basic Medical Sciences, 23(12), 1610.

Ovayolu, A., Ovayolu, G., Yuce, T., Ozek, M. A., Dogan, I., & Bostancieri, N. (2020). Amniotic fluid concentrations of soluble endoglin and endothelial cell-specific molecule-1 in pregnancies complicated with neural tube defects. Journal of Perinatal Medicine, 48(2), 132-138.

Wang, S., Wu, Z., Wei, L., & Zhang, J. (2019). Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma. BMC Endocrine Disorders, 19(1), 1-7.

Gündoğan, F., Bayram, A., Kalkan, M., & Özcan, I. (2018). Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss. The Journal of Laryngology & Otology, 132(11), 995-999.

Schuitemaker, J. H., Cremers, T. I., Van Pampus, M. G., Scherjon, S. A., & Faas, M. M. (2018). Changes in endothelial cell specific molecule 1 plasma levels during preeclamptic pregnancies compared to healthy pregnancies. Pregnancy Hypertension, 12, 58-64.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY8284)

Rat Esm1 ELISA Kit (CAT#: V2LY-0626-LY1295)

Mouse Esm1 ELISA Kit (CAT#: V2LY-0626-LY1491)

Human ESM1 ELISA Kit (CAT#: V2LY-0626-LY3656)

Related Products

Mouse Recombinant ESM1 protein, His Tag (CAT#: V2LY-0526-LY8284)

Mouse Esm1 ELISA Kit (CAT#: V2LY-0626-LY1491)

Mouse Anti-ESM1 Recombinant Antibody (CBFYE-1233) (CAT#: V2LY-0825-LY763)

Human ESM1 ELISA Kit (CAT#: V2LY-0626-LY3656)

Mouse Anti-ESM1 Recombinant Antibody (6D4) (CAT#: V2LY-0825-LY765)

Rat Esm1 ELISA Kit (CAT#: V2LY-0626-LY1295)

Rat Anti-ESM1 Recombinant Antibody (CBFYE-1234) (CAT#: V2LY-0825-LY764)

Rat Anti-ESM1 Recombinant Antibody (CBFYE-1231) (CAT#: V2LY-0825-LY762)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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