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Mouse Anti-ETV4 Recombinant Antibody (G-10) (CBMAB-P0320-YC)

Provided herein is a Mouse monoclonal antibody against Human ETS Variant 4. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ETV4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
G-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ETS Variant 4
Introduction
ETV4L (ETS Variant 4 Like) is a protein coding gene. Gene Ontology annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of the gene is ETV3.
Entrez Gene ID
Human2118
Mouse18612
Rat360635
UniProt ID
HumanP43268
MouseP28322
RatE9PTJ2
Alternative Names
ETS Variant 4; Ets Variant Gene 4 (E1A Enhancer-Binding Protein, E1AF); Polyomavirus Enhancer Activator 3 Homolog; Adenovirus E1A Enhancer-Binding Protein; E1A-F; E1AF; PEA3;
Research Area
Transcriptional activator (PubMed:19307308, PubMed:31552090).

May play a role in keratinocyte differentiation (PubMed:31552090).

(Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'.
Biological Process
Cell differentiation Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.

Wang, J., Sun, C., Li, J., Jiang, H., Qiu, Y., & Gong, M. (2022). Knockdown of ETV4 promotes autophagy‑dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1. Oncology Letters, 23(2), 1-10.

IV, A. N., & Nair, A. S. (2022). Bioinformatics screening of ETV4 transcription factor oncogenes and identifying small‐molecular anticancer drugs. Chemical Biology & Drug Design, 99(2), 277-285.

Wang, L., Zhang, Y., Yang, J., Liu, L., Yao, B., Tian, Z., & He, J. (2021). The Knockdown of ETV4 Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon SLC7A11 Downregulation. DNA and Cell Biology, 40(9), 1211-1221.

Yao, D., Bao, Z., Qian, X., Yang, Y., & Mao, Z. (2021). ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma. Cell Biology International, 45(10), 2129-2139.

Yatagai, Y., Oshima, H., Sakamoto, T., Shigemasa, R., Kitazawa, H., Hyodo, K., ... & Hizawa, N. (2021). Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations. Scientific reports, 11(1), 1-9.

Wang, B., Cai, Y., Li, X., Kong, Y., Fu, H., & Zhou, J. (2021). ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis. Cell Cycle, 20(24), 2607-2618.

Wang, Y., Ding, X., Liu, B., Li, M., Chang, Y., Shen, H., ... & Li, Y. (2020). ETV4 overexpression promotes progression of non–small cell lung cancer by upregulating PXN and MMP1 transcriptionally. Molecular Carcinogenesis, 59(1), 73-86.

Deshmukh, S. K., Singh, A. P., & Singh, S. (2018). ETV4: an emerging target in pancreatic cancer. Oncoscience, 5(9-10), 260.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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