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ETV4

ETV4L (ETS Variant 4 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ETV3.
Full Name
ETS Variant 4
Research Area
Transcriptional activator (PubMed:19307308, PubMed:31552090).

May play a role in keratinocyte differentiation (PubMed:31552090).

(Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'.
Biological Process
Cell differentiation Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.
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Anti-ETV4 antibodies

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Mouse Anti-ETV4 Recombinant Antibody (A2728) (V2LY-0825-LY878)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human, Mouse, Rat
Clone: A2728
Application*: WB, E, IP
Datasheet SDS

Mouse Anti-ETV4 Recombinant Antibody (P0320) (V2LY-0825-LY877)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: P0320
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-ETV4 Recombinant Antibody (E1973) (V2LY-0825-LY876)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: E1973
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ETV4 Recombinant Antibody (1536) (V2LY-0825-LY875)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 1536
Application*: WB, E
Datasheet SDS

Mouse Anti-ETV4 Recombinant Antibody (CBT1014) (V2LY-0625-LY3108)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1014
Application*: WB, E
Datasheet SDS

Mouse Anti-ETV4 Recombinant Antibody (CBT3171) (V2LY-0625-LY2218)

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Target: ETV4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3171
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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