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Mouse Anti-EVL (AA 309-419) Recombinant Antibody (CBFYE-0277) (CBMAB-E0556-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0277
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant from human EVL with GST tag MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 309-419

Target

Full Name
Enah/Vasp-like
Introduction
EVL (Enah/Vasp-Like) is a Protein Coding gene. Diseases associated with EVL include Esophageal Varix and Vein Disease. Among its related pathways are Innate Immune System and Developmental Biology. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is ENAH.
Entrez Gene ID
51466
UniProt ID
Q9UI08
Alternative Names
Enah/Vasp-Like; Ena/Vasodilator-Stimulated Phosphoprotein-Like; RNB6; Ena/VASP-Like Protein
Research Area
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Biological Process
Actin filament organization Source: ProtInc
Actin nucleation Source: InterPro
Actin polymerization or depolymerization Source: UniProtKB
Animal organ morphogenesis Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of ruffle assembly Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of actin filament polymerization Source: GO_Central
Positive regulation of stress fiber assembly Source: UniProtKB
Protein homotetramerization Source: InterPro
Cellular Location
Cytoskeleton; Stress fiber; Lamellipodium. Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.
PTM
Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.By similarity
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For research use only. Not intended for any clinical use.

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