EVL

EVL (Enah/Vasp-Like) is a Protein Coding gene. Diseases associated with EVL include Esophageal Varix and Vein Disease. Among its related pathways are Innate Immune System and Developmental Biology. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is ENAH.

Full Name

Enah/Vasp-like

Research Area

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.

Biological Process

Actin filament organization Source: ProtInc
Actin nucleation Source: InterPro
Actin polymerization or depolymerization Source: UniProtKB
Animal organ morphogenesis Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of ruffle assembly Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of actin filament polymerization Source: GO_Central
Positive regulation of stress fiber assembly Source: UniProtKB
Protein homotetramerization Source: InterPro

Cellular Location

Cytoskeleton; Stress fiber; Lamellipodium. Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.

PTM

Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.By similarity