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Mouse Anti-EVL Recombinant Antibody (1D6) (CBMAB-A2740-LY)

The product is antibody recognizes EVL. The antibody 1D6 immunoassay techniques such as: WB, ELISA.
See all EVL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EVL (NP_057421, 309 a.a. ~ 418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Enah/Vasp-like
Entrez Gene ID
51466
UniProt ID
Q9UI08
Alternative Names
RNB6
Research Area
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
Biological Process
Actin filament organization Source: ProtInc
Actin nucleation Source: InterPro
Actin polymerization or depolymerization Source: UniProtKB
Animal organ morphogenesis Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of epithelial cell migration Source: UniProtKB
Negative regulation of ruffle assembly Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of actin filament polymerization Source: GO_Central
Positive regulation of stress fiber assembly Source: UniProtKB
Protein homotetramerization Source: InterPro
Cellular Location
Cytoskeleton; Stress fiber; Lamellipodium. Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.
PTM
Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC.By similarity
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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