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Rabbit Anti-F2RL2 Recombinant Antibody (EG1161) (CBMAB-EN1391-LY)

The product is antibody recognizes F2RL2. The antibody EG1161 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:10000.
See all F2RL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1161
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human F2RL2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coagulation Factor II Thrombin Receptor Like 2
Introduction
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Entrez Gene ID
2151
UniProt ID
O00254
Alternative Names
Coagulation Factor II Thrombin Receptor Like 2; Thrombin Receptor-Like 2; PAR-3; PAR3; Coagulation Factor II Receptor-Like 2 (Protease-Actovated Receptor 3); Coagulation Factor II (Thrombin) Receptor-Like 2;
Research Area
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Biological Process
Blood coagulation Source: ProtInc
Platelet activation Source: Reactome
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
Response to wounding Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 39-94
Helical: 95-120
Cytoplasmic: 121-128
Helical: 129-148
Extracellular: 149-167
Helical: 168-189
Cytoplasmic: 190-206
Helical: 207-230
Extracellular: 231-260
Helical: 261-280
Cytoplasmic: 281-297
Helical: 298-322
Extracellular: 323-336
Helical: 337-361
Cytoplasmic: 362-374
PTM
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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