F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Full Name

Coagulation Factor II Thrombin Receptor Like 2

Research Area

Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Biological Process

Blood coagulation Source: ProtInc
Platelet activation Source: Reactome
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central
Response to wounding Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 39-94
Helical: 95-120
Cytoplasmic: 121-128
Helical: 129-148
Extracellular: 149-167
Helical: 168-189
Cytoplasmic: 190-206
Helical: 207-230
Extracellular: 231-260
Helical: 261-280
Cytoplasmic: 281-297
Helical: 298-322
Extracellular: 323-336
Helical: 337-361
Cytoplasmic: 362-374

PTM

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.