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Mouse Anti-FAAH Recombinant Antibody (CBXF-2784) (CBMAB-F3497-CQ)

This product is a mouse antibody that recognizes FAAH. The antibody CBXF-2784 can be used for immunoassay techniques such as: ELISA, WB.
See all FAAH antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXF-2784
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa480-579 from human FAAH (NP_001432) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fatty Acid Amide Hydrolase
Introduction
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.
Entrez Gene ID
Human2166
Rat100911581
UniProt ID
HumanO00519
RatP97612
Alternative Names
Fatty Acid Amide Hydrolase; Anandamide Amidohydrolase 1; Oleamide Hydrolase 1; Fatty-Acid Amide Hydrolase 1; EC 3.5.1.n2; EC 3.5.1.99;
Research Area
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788).

Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445).

It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984).

FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
Biological Process
Arachidonic acid metabolic process Source: Reactome
Fatty acid catabolic process Source: UniProtKB
Monoacylglycerol catabolic process Source: UniProtKB
Cellular Location
Cytoskeleton; Endomembrane system. Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Genovese, T., Duranti, A., D’Amico, R., Fusco, R., Impellizzeri, D., Peritore, A. F., ... & Cordaro, M. (2022). Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury. International Journal of Molecular Sciences, 23(5), 2781.

Grieco, M., De Caris, M. G., Maggi, E., Armeli, F., Coccurello, R., Bisogno, T., ... & Businaro, R. (2021). Fatty acid amide hydrolase (FAAH) inhibition modulates amyloid-beta-induced microglia polarization. International Journal of Molecular Sciences, 22(14), 7711.

Rafiei, D., & Kolla, N. J. (2021). Elevated brain fatty acid amide hydrolase induces depressive-like phenotypes in rodent models: A review. International Journal of Molecular Sciences, 22(3), 1047.

Matheson, J., Zhou, X. M. M., Bourgault, Z., & Le Foll, B. (2021). Potential of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and diacylglycerol lipase (DAGL) enzymes as targets for obesity treatment: A narrative review. Pharmaceuticals, 14(12), 1316.

Schmidt, M. E., Liebowitz, M. R., Stein, M. B., Grunfeld, J., Van Hove, I., Simmons, W. K., ... & Drevets, W. C. (2021). The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study. Neuropsychopharmacology, 46(5), 1004-1010.

Chiurchiù, V., Scipioni, L., Arosio, B., Mari, D., Oddi, S., & Maccarrone, M. (2021). Anti-inflammatory effects of fatty acid amide hydrolase inhibition in monocytes/macrophages from alzheimer’s disease patients. Biomolecules, 11(4), 502.

Tripathi, R. K. P. (2020). A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. European Journal of Medicinal Chemistry, 188, 111953.

Mayo, L. M., Asratian, A., Lindé, J., Morena, M., Haataja, R., Hammar, V., ... & Heilig, M. (2020). Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: a randomized, controlled experimental medicine trial. Biological psychiatry, 87(6), 538-547.

Brunetti, L., Loiodice, F., Piemontese, L., Tortorella, P., & Laghezza, A. (2019). New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation: Miniperspective. Journal of Medicinal Chemistry, 62(24), 10995-11003.

Balsevich, G., Sticht, M., Bowles, N. P., Singh, A., Lee, T. T., Li, Z., ... & Hill, M. N. (2018). Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proceedings of the National Academy of Sciences, 115(29), 7605-7610.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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