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Mouse Anti-ESYT2 Recombinant Antibody (1E10) (CBMAB-A2825-LY)

The product is antibody recognizes FAM62B. The antibody 1E10 immunoassay techniques such as: WB, ELISA.
See all ESYT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FAM62B (AAH13957, 1 a.a. ~ 358 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Extended Synaptotagmin 2
Entrez Gene ID
57488
UniProt ID
A0FGR8
Alternative Names
CHR2SYT; ESYT2; KIAA1228
Research Area
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).
Biological Process
Endocytosis Source: UniProtKB-KW
Endoplasmic reticulum-plasma membrane tethering Source: InterPro
Lipid transport Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Cell membrane. Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).
Topology
Cytoplasmic: 1-103
Helical: 104-124
Lumenal: 125-127
Helical: 128-148
Cytoplasmic: 149-921
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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