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Rat Anti-FCMR Recombinant Antibody (4B5) (CBMAB-F2594-CQ)

This product is a rat antibody that recognizes FCMR. The antibody 4B5 can be used for immunoassay techniques such as: FC, ICC.
See all FCMR antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
4B5
Antibody Isotype
IgG1, κ
Application
FC, ICC

Basic Information

Immunogen
Extracellular domain of the receptor mouse Fcμ, Fc fusion protein
Specificity
Mouse
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol, pH 7.2
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc fragment of IgM receptor
Introduction
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).
Entrez Gene ID
69169
UniProt ID
A1KXC4
Alternative Names
Fc Fragment Of IgM Receptor; Regulator Of Fas-Induced Apoptosis Toso; Fas Apoptotic Inhibitory Molecule 3; IgM Fc Fragment Receptor; FAIM3; TOSO; Immunoglobulin Mu Fc Receptor; IgM Fc Receptor; Fc Mu Receptor;
Research Area
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Biological Process
Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc
Cellular Location
Isoform 1: Membrane
Isoform 3: Secreted. Detected in the serum.
Topology
Extracellular: 18-251
Helical: 252-272
Cytoplasmic: 273-390
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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