FCMR

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).

Full Name

Fc fragment of IgM receptor

Research Area

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Biological Process

Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc

Cellular Location

Isoform 1: Membrane
Isoform 3: Secreted. Detected in the serum.

Topology

Extracellular: 18-251
Helical: 252-272
Cytoplasmic: 273-390