FCMR

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).
Full Name
Fc fragment of IgM receptor
Research Area
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Biological Process
Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc
Cellular Location
Isoform 1: Membrane
Isoform 3: Secreted. Detected in the serum.
Topology
Extracellular: 18-251
Helical: 252-272
Cytoplasmic: 273-390
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Anti-FCMR antibodies

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Human Recombinant FCMR protein, hFc Tag (V2LY-0526-LY4039)

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Target: FCMR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-251
Tag: hFc Tag
Datasheet SDS

Mouse Anti-FCMR Recombinant Antibody (CBXF-2929) (V2LY-0925-LY1057)

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Target: FCMR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2929
Application*: IH
Datasheet SDS

Mouse Anti-FCMR Recombinant Antibody (CBXF-0472) (V2LY-0925-LY1053)

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Target: FCMR
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-0472
Application*: WB, F
Datasheet SDS

Mouse Anti-FCMR Recombinant Antibody (CBXF-0473) (V2LY-0925-LY1052)

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Target: FCMR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-0473
Application*: E, WB, IP
Functional Assay
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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