Mouse Anti-FCMR Recombinant Antibody (CBXF-0472) (V2LY-0925-LY1053)

Name: Mouse Anti-FCMR Recombinant Antibody (CBXF-0472)
SKU: V2LY-0925-LY1053
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0472

Application

WB, FC

Immunogen

Recombinant human Fc mu R/FAIM3 (Arg18-Gly251).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

Application	Note
WB	2 µg/ml
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc fragment of IgM receptor

Entrez Gene ID

9214

UniProt ID

O60667

Research Area

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Biological Process

Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc

Cellular Location

Isoform 1: Membrane
Isoform 3: Secreted. Detected in the serum.

Topology

Extracellular: 18-251
Helical: 252-272
Cytoplasmic: 273-390

Ling, W. L., & Gan, S. K. (2022). The contributory effects of the VH families and CH regions of multimeric IgM on its interaction with Fc (mu) R, and antigen. bioRxiv.

Flowers, E. M., Neely, H. R., Guo, J., Almeida, T., Ohta, Y., Castro, C. D., & Flajnik, M. F. (2021). Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport. European journal of immunology, 51(11), 2590-2606.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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