Human Recombinant FCMR protein, hFc Tag (V2LY-0526-LY4039)

Name: Human Recombinant FCMR protein, hFc Tag
SKU: V2LY-0526-LY4039
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant FCMR protein, hFc Tag consist of Amino Acid: 1-251 and predicts a molecular mass of 53 kDa.

Molecule Mass

53 kDa

Sequence

Amino Acid: 1-251

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>65% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fc fragment of IgM receptor

Research Area

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Biological Process

Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ProtInc

Cellular Location

Isoform 1: Membrane
Isoform 3: Secreted. Detected in the serum.

Topology

Extracellular: 18-251
Helical: 252-272
Cytoplasmic: 273-390

Ling, W. L., & Gan, S. K. (2022). The contributory effects of the VH families and CH regions of multimeric IgM on its interaction with Fc (mu) R, and antigen. bioRxiv.

Flowers, E. M., Neely, H. R., Guo, J., Almeida, T., Ohta, Y., Castro, C. D., & Flajnik, M. F. (2021). Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport. European journal of immunology, 51(11), 2590-2606.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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