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Mouse Anti-FCRL4 Recombinant Antibody (CBXF-2595) (CBMAB-F0168-CQ)

This product is a mouse antibody that recognizes FCRL4. The antibody CBXF-2595 can be used for immunoassay techniques such as: FC.
See all FCRL4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2595
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0-derived recombinant human FCRL4/FcRH4, Gln16-Asp385, Accession # NP_112572
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc Receptor Like 4
Introduction
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.
Entrez Gene ID
83417
UniProt ID
Q96PJ5
Alternative Names
Fc Receptor Like 4; Immune Receptor Translocation-Associated Protein 1; Fc Receptor Homolog 4; IFGP Family Protein 2; FcR-Like Protein 4; HIFGP2; FCRH4; IRTA1; Immunoglobulin Superfamily Receptor Translocation Associated 1;
Research Area
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
Topology
Extracellular: 20-387
Helical: 388-408
Cytoplasmic: 409-515
PTM
Phosphorylated on cytoplasmic tyrosines upon activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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