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Mouse Anti-FDPS Recombinant Antibody (3A6) (CBMAB-A2914-LY)

The product is antibody recognizes FDPS. The antibody 3A6 immunoassay techniques such as: sELISA, ELISA.
See all FDPS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A6
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
FDPS (NP_001995.1, 320 a.a. ~ 419 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Introduction
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene
Entrez Gene ID
2224
UniProt ID
P14324
Alternative Names
FPPS; FPS
Research Area
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Biological Process
Cholesterol biosynthetic process Source: ProtInc
Farnesyl diphosphate biosynthetic process Source: GO_Central
Geranyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
Cellular Location
Cytoplasm
Involvement in disease
Porokeratosis 9, multiple types (POROK9):
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.

Oike, A., Iwata, S., Hirayama, A., Ono, Y., Nagasato, Y., Kawabata, Y., ... & Shigemura, N. (2022). Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells. Scientific Reports, 12(1), 1-15.

Jin, T., Lu, J., Lv, Q., Gong, Y., Feng, Z., Ying, H., ... & Jiang, D. (2022). Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline. Molecular Medicine, 28(1), 1-16.

Tang, H. V., Berryman, D. L., Mendoza, J., Yactayo‐Chang, J. P., Li, Q. B., Christensen, S. A., ... & Block, A. K. (2022). Dedicated farnesyl diphosphate synthases circumvent isoprenoid‐derived growth‐defense tradeoffs in Zea mays. The Plant Journal, 112(1), 207-220.

Lin, P., Yan, Z. F., & Li, C. T. (2020). Effects of Exogenous Elicitors on Triterpenoids Accumulation and Expression of Farnesyl Diphosphate Synthase Gene in Inonotus obliquus. Biotechnology and Bioprocess Engineering, 25(4), 580-588.

Wang, X., Sun, T., Sun, J., Wang, S., Ma, Y., Liu, Z., ... & Zou, L. (2020). Molecular cloning, characterisation, and heterologous expression of farnesyl diphosphate synthase from Sanghuangporus baumii. Molecular Biotechnology, 62(2), 132-141.

Fei, Y., Li, N., Zhang, D. H., & Xu, J. W. (2019). Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum. Microbial cell factories, 18(1), 1-9.

Wang, Z., Guo, H., Zhang, Y., Lin, L., Cui, M., Long, Y., & Xing, Z. (2019). DNA methylation of farnesyl pyrophosphate synthase, squalene synthase, and squalene epoxidase gene promoters and effect on the saponin content of Eleutherococcus Senticosus. Forests, 10(12), 1053.

Kim, H. Y., Kim, D. K., Bae, S. H., Gwak, H., Jeon, J. H., Kim, J. K., ... & Jang, H. (2018). Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Experimental & molecular medicine, 50(10), 1-12.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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