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Mouse Anti-FGFRL1 (AA 121-321) Recombinant Antibody (CBXF-0633) (CBMAB-F0413-CQ)

This product is a mouse antibody that recognizes FGFRL1 (AA 121-321). The antibody CBXF-0633 can be used for immunoassay techniques such as: ELISA.
See all FGFRL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0633
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 121-321

Target

Full Name
Fibroblast Growth Factor Receptor Like 1
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Entrez Gene ID
53834
UniProt ID
Q8N441
Alternative Names
Fibroblast Growth Factor Receptor Like 1; Fibroblast Growth Factor Receptor 5; FGF Homologous Factor Receptor; FGF Receptor-Like Protein 1; FGFR-Like Protein; FGFR-5; FGFR5; FHFR; Fibroblast Growth Factor Receptor-Like 1;
Function
Has a negative effect on cell proliferation.
Biological Process
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Diaphragm development Source: Ensembl
Heart valve morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Skeletal system development Source: Ensembl
Ventricular septum morphogenesis Source: Ensembl
Cellular Location
Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Topology
Extracellular: 25-378
Helical: 379-399
Cytoplasmic: 400-504

Guan, L., Dong, Y., Chen, S., Wang, C., Feng, L., Xie, Y., & Tang, X. (2022). Overexpression of fibroblast growth factor receptor like 1 (FGFRL1) inhibits proliferation and migration of HCT116 human colon cancer cells, and promotes their apoptosis. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 38(3), 251-256.

Cho, H. W., Jin, H. S., & Eom, Y. B. (2022). FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis. Plos one, 17(8), e0273237.

Gofin, Y., Mackay, L. P., Machol, K., Keswani, S., Potocki, L., Di Gregorio, E., ... & Scott, D. A. (2021). Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans. American Journal of Medical Genetics Part A, 185(3), 836-840.

Zhuang, L., Vogel, M., Villiger, P. M., & Trueb, B. (2020). Dissecting the interaction of FGF8 with receptor FGFRL1. Biomolecules, 10(10), 1399.

Chen, R., Li, D., Zheng, M., Chen, B., Wei, T., Wang, Y., ... & Fang, S. (2020). FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1. Journal of cellular and molecular medicine, 24(3), 2123-2134.

Fan, Y., Li, H., Yu, Z., Dong, W., Cui, X., Ma, J., & Li, S. (2020). Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Bioscience reports, 40(1).

Wang, L., He, J., Hu, H., Tu, L., Sun, Z., Liu, Y., & Luo, F. (2020). Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. Journal of Cellular and Molecular Medicine, 24(11), 6324-6339.

Gerber, S. D., Beauchamp, P., Zhuang, L., Villiger, P. M., & Trueb, B. (2020). Functional domains of the FgfrL1 receptor. Developmental biology, 461(1), 43-54.

Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16(2), 2229-2236.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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