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Rabbit Anti-FGFRL1 Recombinant Antibody (EG1198) (CBMAB-EN1449-LY)

The product is antibody recognizes FGRL1. The antibody EG1198 immunoassay techniques such as: WB: 1:500~1:3000 ELISA: 1:40000.
See all FGFRL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1198
Antibody Isotype
IgG
Application
WB: 1:500~1:3000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from Internal of human FGFRL1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fibroblast Growth Factor Receptor Like 1
Entrez Gene ID
Human53834
Mouse116701
UniProt ID
HumanQ8N441
MouseQ91V87
Function
Has a negative effect on cell proliferation.
Biological Process
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Diaphragm development Source: Ensembl
Heart valve morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Skeletal system development Source: Ensembl
Ventricular septum morphogenesis Source: Ensembl
Cellular Location
Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Topology
Extracellular: 25-378
Helical: 379-399
Cytoplasmic: 400-504

Guan, L., Dong, Y., Chen, S., Wang, C., Feng, L., Xie, Y., & Tang, X. (2022). Overexpression of fibroblast growth factor receptor like 1 (FGFRL1) inhibits proliferation and migration of HCT116 human colon cancer cells, and promotes their apoptosis. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 38(3), 251-256.

Cho, H. W., Jin, H. S., & Eom, Y. B. (2022). FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis. Plos one, 17(8), e0273237.

Gofin, Y., Mackay, L. P., Machol, K., Keswani, S., Potocki, L., Di Gregorio, E., ... & Scott, D. A. (2021). Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans. American Journal of Medical Genetics Part A, 185(3), 836-840.

Zhuang, L., Vogel, M., Villiger, P. M., & Trueb, B. (2020). Dissecting the interaction of FGF8 with receptor FGFRL1. Biomolecules, 10(10), 1399.

Chen, R., Li, D., Zheng, M., Chen, B., Wei, T., Wang, Y., ... & Fang, S. (2020). FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1. Journal of cellular and molecular medicine, 24(3), 2123-2134.

Fan, Y., Li, H., Yu, Z., Dong, W., Cui, X., Ma, J., & Li, S. (2020). Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Bioscience reports, 40(1).

Wang, L., He, J., Hu, H., Tu, L., Sun, Z., Liu, Y., & Luo, F. (2020). Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. Journal of Cellular and Molecular Medicine, 24(11), 6324-6339.

Gerber, S. D., Beauchamp, P., Zhuang, L., Villiger, P. M., & Trueb, B. (2020). Functional domains of the FgfrL1 receptor. Developmental biology, 461(1), 43-54.

Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16(2), 2229-2236.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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