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Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706) (CBMAB-F0909-CQ)

This product is a mouse antibody that recognizes FKBP1B. The antibody CBXF-0706 can be used for immunoassay techniques such as: WB, IHC-P.
See all FKBP1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0706
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FK506 binding protein 1B, 12.6 kDa
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
Entrez Gene ID
2281
UniProt ID
P68106
Alternative Names
FK506 Binding Protein 1B; FK506 Binding Protein 1B, 12.6 KDa; 12.6 KDa FK506-Binding Protein; Immunophilin FKBP12.6; 12.6 KDa FKBP; PPIase FKBP1B; Calstabin 2; EC 5.2.1.8; FKBP-12.6; H-FKBP-12; Rotamase; FKBP12.6;
Function
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Biological Process
de novo' protein folding Source: BHF-UCL
Calcium-mediated signaling using intracellular calcium source Source: BHF-UCL
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Chaperone-mediated protein folding Source: GO_Central
Insulin secretion Source: Ensembl
Negative regulation of heart rate Source: BHF-UCL
Negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Negative regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Negative regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Neuronal action potential propagation Source: Ensembl
Positive regulation of axon regeneration Source: Ensembl
Positive regulation of sequestering of calcium ion Source: BHF-UCL
Protein maturation by protein folding Source: BHF-UCL
Protein peptidyl-prolyl isomerization Source: BHF-UCL
Protein refolding Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cytosolic calcium ion concentration Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: Ensembl
Response to glucose Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to redox state Source: BHF-UCL
Response to vitamin E Source: Ensembl
Smooth muscle contraction Source: Ensembl
T cell proliferation Source: Ensembl
Cellular Location
Cytoplasm; Sarcoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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