FKBP1B

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq]

Full Name

FK506 binding protein 1B, 12.6 kDa

Function

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Biological Process

de novo' protein folding Source: BHF-UCL
Calcium-mediated signaling using intracellular calcium source Source: BHF-UCL
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Chaperone-mediated protein folding Source: GO_Central
Insulin secretion Source: Ensembl
Negative regulation of heart rate Source: BHF-UCL
Negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Negative regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Negative regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Neuronal action potential propagation Source: Ensembl
Positive regulation of axon regeneration Source: Ensembl
Positive regulation of sequestering of calcium ion Source: BHF-UCL
Protein maturation by protein folding Source: BHF-UCL
Protein peptidyl-prolyl isomerization Source: BHF-UCL
Protein refolding Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cytosolic calcium ion concentration Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: Ensembl
Response to glucose Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to redox state Source: BHF-UCL
Response to vitamin E Source: Ensembl
Smooth muscle contraction Source: Ensembl
T cell proliferation Source: Ensembl

Cellular Location

Cytoplasm; Sarcoplasmic reticulum