• Home
  • FKBP1B
  • Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706)

Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706) (V2LY-0925-LY2051)

See all FKBP1B antibodies
Go to compare Compare Online Inquiry
Published Data
V2LY-0925-LY2051-1
Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706) (V2LY-0925-LY2051) in IP
CHSSC induced dissociation of the FKBP12.6-RyR2 complex as a protective mechanism against arrhythmia. Co-immunoprecipitation was used to detect the interaction between FKBP12.6 and RyR2 in each group. ...View More
Chen, L., Liu, R., Wang, W., Tang, C., Ran, J., Huang, W., ... & Liu, J. (2022). Chai-Hu-San-Shen Capsule Ameliorates Ventricular Arrhythmia Through Inhibition of the CaMKII/FKBP12. 6/RyR2/Ca2+ Signaling Pathway in Rats with Myocardial Ischemia. Evidence-Based Complementary and Alternative Medicine, 2022(1), 2670473.
V2LY-0925-LY2051-2
Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706) (V2LY-0925-LY2051) in Immunoblot
Representative immunoblot images of Ryanodine receptor type 2 (RyR2) and three of its accessory proteins (sorcin, FKBP12.6, and calsequestrin-2 (CSQ2)) from MAs with (+) and without (-) ALDO (10 nM for 24 h). The GAPDH enzyme was used as the loading control. ...View More
Salazar-Enciso, R., Guerrero-Hernández, A., Gómez, A. M., Benitah, J. P., & Rueda, A. (2022). Aldosterone-Induced Sarco/Endoplasmic Reticulum Ca2+ Pump Upregulation Counterbalances Cav1. 2-Mediated Ca2+ Influx in Mesenteric Arteries. Frontiers in Physiology, 13, 834220.
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXF-0706
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Amino acids 38-108 mapping at the C-terminal of human FKBP12.6.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
FK506 binding protein 1B, 12.6 kDa
Entrez Gene ID
2281
UniProt ID
P68106
Function
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Biological Process
de novo' protein folding Source: BHF-UCL
Calcium-mediated signaling using intracellular calcium source Source: BHF-UCL
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Chaperone-mediated protein folding Source: GO_Central
Insulin secretion Source: Ensembl
Negative regulation of heart rate Source: BHF-UCL
Negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Negative regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Negative regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Neuronal action potential propagation Source: Ensembl
Positive regulation of axon regeneration Source: Ensembl
Positive regulation of sequestering of calcium ion Source: BHF-UCL
Protein maturation by protein folding Source: BHF-UCL
Protein peptidyl-prolyl isomerization Source: BHF-UCL
Protein refolding Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cytosolic calcium ion concentration Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: Ensembl
Response to glucose Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to redox state Source: BHF-UCL
Response to vitamin E Source: Ensembl
Smooth muscle contraction Source: Ensembl
T cell proliferation Source: Ensembl
Cellular Location
Cytoplasm; Sarcoplasmic reticulum

Barajas-Martinez, H., Smith, M., Hu, D., Goodrow, R. J., Puleo, C., Hasdemir, C., ... & Cordeiro, J. M. (2020). Susceptibility to ventricular arrhythmias resulting from mutations in FKBP1B, PXDNL, and SCN9A evaluated in hiPSC cardiomyocytes. Stem cells international, 2020.

Kuznik, B. I., Davydov, S. O., Popravka, E. S., Lin’kova, N. S., Kozina, L. S., & Khavinson, V. K. (2019). Epigenetic mechanisms of peptide-driven regulation and neuroprotective protein FKBP1b. Molecular biology, 53, 299-307.

Kang, S., Shin, D., Mathias, D. K., Londono-Renteria, B., Noh, M. Y., Colpitts, T. M., ... & Hong, Y. S. (2019). Homologs of human dengue-resistance genes, FKBP1B and ATCAY, confer antiviral resistance in Aedes aegypti mosquitoes. Insects, 10(2), 46.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FKBP1B Recombinant Antibody (CBXF-0706)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-FKBP1B Recombinant Antibody (CBXF-3046) (CAT#: V2LY-0925-LY2052)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry