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Rabbit Anti-FNDC5 Recombinant Antibody (CBXF-1096) (CBMAB-F0932-CQ)

This product is a rabbit antibody that recognizes FNDC5. The antibody CBXF-1096 can be used for immunoassay techniques such as: WB.
See all FNDC5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1096
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibronectin Type III Domain Containing 5
Introduction
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human252995
Mouse384061
Rat260327
UniProt ID
HumanQ8NAU1
MouseQ8K4Z2
RatQ8K3V5
Alternative Names
Fibronectin Type III Domain Containing 5; Fibronectin Type III Repeat-Containing Protein 2; Irisin; FRCP2; Fibronectin Type III Domain-Containing Protein 5;
Function
Irisin:
Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Biological Process
Positive regulation of brown fat cell differentiation Source: UniProtKB
Response to muscle activity Source: UniProtKB
Cellular Location
Peroxisome membrane; Cell membrane. Imported in peroxisomes through the PEX5 receptor pathway.
Irisin: Secreted. Detected in the blood of individuals subjected to endurance exercise.
Topology
Extracellular: 32-152
Helical: 153-173
Cytoplasmic: 174-212
PTM
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.

Waseem, R., Shamsi, A., Mohammad, T., Hassan, M., Kazim, S. N., Chaudhary, A. A., ... & Islam, A. (2022). FNDC5/irisin: physiology and pathophysiology. Molecules, 27(3), 1118.

Cebulski, K., Nowińska, K., Jablońska, K., Romanowicz, H., Smolarz, B., Dzięgiel, P., & Podhorska-Okołów, M. (2022). Expression of irisin/FNDC5 in breast cancer. International Journal of Molecular Sciences, 23(7), 3530.

Maak, S., Norheim, F., Drevon, C. A., & Erickson, H. P. (2021). Progress and Challenges in the Biology of FNDC5 and Irisin. Endocrine reviews, 42(4), 436-456.

Pignataro, P., Dicarlo, M., Zerlotin, R., Zecca, C., Dell’Abate, M. T., Buccoliero, C., ... & Grano, M. (2021). FNDC5/Irisin system in neuroinflammation and neurodegenerative diseases: update and novel perspective. International Journal of Molecular Sciences, 22(4), 1605.

Rabiee, F., Lachinani, L., Ghaedi, S., Nasr-Esfahani, M. H., Megraw, T. L., & Ghaedi, K. (2020). New insights into the cellular activities of Fndc5/Irisin and its signaling pathways. Cell & Bioscience, 10, 1-10.

Zhang, X., Hu, C., Kong, C. Y., Song, P., Wu, H. M., Xu, S. C., ... & Tang, Q. Z. (2020). FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT. Cell Death & Differentiation, 27(2), 540-555.

Cao, R. Y., Zheng, H., Redfearn, D., & Yang, J. (2019). FNDC5: A novel player in metabolism and metabolic syndrome. Biochimie, 158, 111-116.

Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., ... & De Felice, F. G. (2019). Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature medicine, 25(1), 165-175.

Yu, Q., Kou, W., Xu, X., Zhou, S., Luan, P., Xu, X., ... & Peng, W. (2019). FNDC5/Irisin inhibits pathological cardiac hypertrophy. Clinical Science, 133(5), 611-627.

Young, M. F., Valaris, S., & Wrann, C. D. (2019). A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases. Progress in cardiovascular diseases, 62(2), 172-178.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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