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Mouse Anti-GMFB (AA 1-142) Recombinant Antibody (CBFYH-3450) (CBMAB-H3998-FY)

This product is mouse antibody that recognizes GMFB. The antibody CBFYH-3450 can be used for immunoassay techniques such as: WB.
See all GMFB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3450
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human GMF-beta, Met1-His142
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-142

Target

Full Name
Glia Maturation Factor Beta
Introduction
The concentration of GMFB in serum did not change significantly with age.
Entrez Gene ID
2764
UniProt ID
P60983
Alternative Names
GMF
Function
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Biological Process
Actin filament debranching Source: GO_Central
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Nervous system development Source: ProtInc
Protein phosphorylation Source: ProtInc
PTM
Phosphorylated; stimulated by phorbol ester.

Liu, C., Sun, W., Zhu, T., Shi, S., Zhang, J., Wang, J., ... & Lu, L. (2022). Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biology, 52, 102292.

Yin, G., Zeng, W., Li, R., Zeng, M., Chen, R., Liu, Y., ... & Wang, Y. (2022). Glia Maturation Factor-β Supports Liver Regeneration by Remodeling Actin Network to Enhance STAT3 Proliferative Signals. Cellular and Molecular Gastroenterology and Hepatology, 14(5), 1123-1145.

Zhu, T., Wang, T., Feng, Z., Gao, F., Zhang, J., Jin, C., ... & Lu, L. (2022). Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma. Frontiers in Oncology, 12.

Sun, W., Hu, C., Wang, T., Wang, J., Zhang, J., Gao, F., ... & Lu, L. (2021). Glia maturation factor beta as a novel biomarker and therapeutic target for hepatocellular carcinoma. Frontiers in Oncology, 11, 744331.

Teruya, K., Oguma, A., Arai, K., Nishizawa, K., Iwabuchi, S., Watanabe-Matsui, M., ... & Doh-Ura, K. (2021). Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice. Biochemical and biophysical research communications, 560, 105-111.

Wang, J., Awuti, M., Jiang, X., Zhang, J., Lyu, Y., Lu, L., & Xu, G. T. (2018). Effect of Glia Maturation Factor beta (GMFB) on Retinal Pigment Epithelium in Diabetic Retinopathy. Investigative Ophthalmology & Visual Science, 59(9), 3979-3979.

Xu, F. F., Zhang, Z. B., Wang, Y. Y., & Wang, T. H. (2018). Brain-derived glia maturation factor β participates in lung injury induced by acute cerebral ischemia by increasing ROS in endothelial cells. Neuroscience bulletin, 34, 1077-1090.

Yin, G., Du, M., Li, R., Li, K., Huang, X., Duan, D., ... & Wu, B. (2018). Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish. Experimental Neurology, 305, 129-138.

Fan, J., Fong, T., Chen, X., Chen, C., Luo, P., & Xie, H. (2018). Glia maturation factor-β: A potential therapeutic target in neurodegeneration and neuroinflammation. Neuropsychiatric disease and treatment, 495-504.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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