Rabbit Anti-GTPBP2 Recombinant Antibody (EG1468) (CBMAB-EN1754-LY)

The product is antibody recognizes GTPBP2. The antibody EG1468 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all GTPBP2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG1468

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GTPBP2.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

GTP binding protein 2

Introduction

GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.

Entrez Gene ID

Human	54676
Mouse	56055

UniProt ID

Human	Q9BX10
Mouse	Q3UJK4

Alternative Names

JABELS

Biological Process

Translational elongation Source: GO_Central

Cellular Location

Extracellular region; Platelet alpha granule lumen

Involvement in disease

Jaberi-Elahi syndrome (JABELS):
An autosomal recessive disorder characterized by developmental delay and intellectual disability. Additional variable features include ataxic gait and abnormal movements, visual impairment, microcephaly, abnormal foot or hand posturing, kyphoscoliosis, dysmorphic facial features or seizures. Brain imaging typically shows cerebellar atrophy and hypoplasia of the corpus callosum.

References

Jie, L., Cong, L., Conghui, W., & Ying, G. (2021). GTPBP2 positively regulates the invasion, migration and proliferation of non-small cell lung cancer. Journal of Cancer, 12(13), 3819.

Rad, I. A., Vahabi, A., & Akbariazar, E. (2021). A novel GTPBP2 splicing mutation in two siblings affected with microcephaly, generalized muscular atrophy, and hypotrichosis. Clinical Case Reports, 9(2), 732.

Carter, M. T., Venkateswaran, S., Shapira‐Zaltsberg, G., Davila, J., Humphreys, P., Care4Rare Canada Consortium, ... & Boycott, K. M. (2019). Clinical delineation of GTPBP2‐associated neuro‐ectodermal syndrome: Report of two new families and review of the literature. Clinical Genetics, 95(5), 601-606.

Zinoviev, A., Goyal, A., Jindal, S., LaCava, J., Komar, A. A., Rodnina, M. V., ... & Pestova, T. V. (2018). Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2. Genes & Development, 32(17-18), 1226-1241.

Bertoli-Avella, A. M., Garcia-Aznar, J. M., Brandau, O., Al-Hakami, F., Yüksel, Z., Marais, A., ... & Bauer, P. (2018). Biallelic inactivating variants in the GTPBP2 gene cause a neurodevelopmental disorder with severe intellectual disability. European Journal of Human Genetics, 26(4), 592-598.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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